Examination of HY Response: T Cell Expansion, Immunodominance, and Cross-Priming Revealed by HY Tetramer Analysis

Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis.

We have applied MHC class I tetramers representing the two H2(b) MHC class I-restricted epitopes of the mouse male-specific minor transplantation Ag, HY, to directly determine the extent of expansion and immunodominance within the CD8+ T cell compartment following exposure to male tissue. Immunization with male bone marrow (BM), spleen, dendritic cells (DCs) and by skin graft led to rapid expan...

Dialogues and HY-arguments

This paper introduces a new class called hang yourself (HY) arguments into the theory of defeasible argumentation. The novelty of such arguments is that they are inherently destructive: they cannot be used to support conclusions but only to attack other arguments. In this paper it is described what these arguments are, how they can be formalized, and what the formal consequences are of adding t...

Asynchronous differentiation of CD8 T cells that recognize dominant and cryptic antigens.

Restriction of T cell responses to a few epitopes (immunodominance) is a central feature of immune responses. We analyzed the entire transcriptome of effector CD8 T cells specific for a dominant (H7(a)) and a cryptic (HY) mouse Ag and performed a longitudinal analysis of selected T cell differentiation markers. We found that Ag specificity had a relatively modest influence on the repertoire of ...

Identification of the Immunodominant HY

Preliminary Ranking Study of Hy

Central Electricity Authority have completed the preliminary ranking study of hydro electric schemes to harness the balance hydro electric potential in the country. Hon’ble Union Minister of Power Shri Suresh Prabhu released the report on "Preliminary Ranking Study of Hydro Electric Schemes" on 5th February 2002 at the International Conference and Business Meet on Non-fossil fuel generation org...